2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-145981
    m7GpppCpG
    m7GpppCpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppCpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.
    m7GpppCpG
  • HY-152683
    3-(2-Pyridinylmethyl)uridine
    N3-[(Pyrid-2-yl)methyl]uridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    3-(2-Pyridinylmethyl)uridine
  • HY-137658A
    Purine riboside-5'-O-triphosphate sodium
    Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM.
    Purine riboside-5'-O-triphosphate sodium
  • HY-16445BR
    CNDAC hydrochloride (Standard)
    Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity.
    CNDAC hydrochloride (Standard)
  • HY-106934AR
    Peldesine dihydrochloride (Standard)
    Peldesine (dihydrochloride) (Standard) is the analytical standard of Peldesine (dihydrochloride). This product is intended for research and analytical applications. Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.
    Peldesine dihydrochloride (Standard)
  • HY-172557
    2'(3')-Br-ANT-GTP tetrasodium
    2'(3')-Br-ANT-GTP tetrasodium is a derivative of GTP. 2'(3')-Br-ANT-GTP tetrasodium can be excited at 350 nm and emit at 380-550 nm.
    2'(3')-Br-ANT-GTP tetrasodium
  • HY-134033A
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium (2'-fluoro dATP) is a fluorinated derivative of ATP (HY-B2176). 2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium is a substrate and an inhibitor for E.coli DNA-dependent RNA polymerase, with a Ki of 200 µM.
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium
  • HY-B0158S8
    Cytidine-d13
    		Chemical
    Cytidine-d13 (Cytosine β-D-riboside-d13) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-d<sub>13</sub>
  • HY-112581S
    5-Methoxyuridine-d3
    5-Methoxyuridine-d3 is the deuterium labeled 5-Methoxyuridine (HY-112581). 5-Methoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methoxyuridine-d<sub>3</sub>
  • HY-172731
    8-Oxo-dATP lithium
    8-Oxo-dATP lithium, as an oxidized purine nucleoside triphosphate, is hydrolyzed by MTH1 into monophosphates, thereby preventing errors caused by its misincorporation during DNA replication or transcription.
    8-Oxo-dATP lithium
  • HY-154537
    3’-O-Methyl inosine
    3’-O-Methyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-Methyl inosine
  • HY-171522
    LNA-AMP
    LNA-AMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-AMP
  • HY-156998
    Troxacitabine triphosphate
    Troxacitabine triphosphate (TRX-TP) is a good substrate for replicative and repair DNA polymerases in vitro.
    Troxacitabine triphosphate
  • HY-171533
    LNA-CTP
    LNA-CTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-CTP
  • HY-152764
    4’-α-C-Methyluridine
    4’-α-C-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    4’-α-C-Methyluridine
  • HY-177197
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine is a nucleotide analogue used in nucleic acid synthesis.
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine
  • HY-152654
    4′-Thiocytidine
    4′-Thiocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4′-Thiocytidine
  • HY-152303S
    N6-(4-Methoxybenzyl)adenosine-d3
    N6-(4-Methoxybenzyl)adenosine-d3 is deuterium labeled N6-(4-Methoxybenzyl)adenosine. N6-(4-Methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-(4-Methoxybenzyl)adenosine-d<sub>3</sub>
  • HY-171532
    LNA-ATP
    LNA-ATP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-ATP
  • HY-154171
    Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one
    Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one (Compound dP) exhibits mutagenicity for Escherichia coli and Salmonella typhimurium, that induces the conversion between GC and AT through replication error. eoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one is stable in Escherichia coli, and can be detected at wavelength >300 nM.
    Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one